In vivo Antimalarial Activity of α‐Mangostin and the New Xanthone δ‐Mangostin
Identifieur interne : 000F49 ( Main/Exploration ); précédent : 000F48; suivant : 000F50In vivo Antimalarial Activity of α‐Mangostin and the New Xanthone δ‐Mangostin
Auteurs : Yulieth Upegui [Colombie] ; Sara M. Robledo [Colombie] ; Juan Fernando Gil Romero [Colombie] ; Winston Qui Ones [Colombie] ; Rosendo Archbold [Colombie] ; Fernando Torres [Colombie] ; Gustavo Escobar [Colombie] ; Bibiana Nari O [Colombie] ; Fernando Echeverri [Colombie]Source :
- Phytotherapy Research [ 0951-418X ] ; 2015-08.
Abstract
Based on the previously reported in vitro antiplasmodial activity of several xanthones from Garcinia mangostana, two xanthones, α‐mangostin and a new compound, δ‐mangostin, were isolated from mangosteen husk, and the in vitro antiplasmodial and cytotoxic effects were determined. α‐Mangostin was more active against the resistant Plasmodium falciparum chloroquine‐resistant (FCR3) strain (IC50 = 0.2 ± 0.01 μM) than δ‐mangostin (IC50 = 121.2 ± 1.0 μM). Furthermore, the therapeutic response according to the administration route was evaluated in a Plasmodium berghei malarial murine model. The greatest therapeutic response was obtained with intraperitoneal administration; these xanthones reduced parasitemia by approximately 80% with a daily dose of 100 mg/kg administered twice a day for 7 days of treatment. Neither compound was effective by oral administration. Noticeable toxicological effects were not observed. In addition to the antimalarial effect of these xanthones isolated from G. mangostana husk, the availability of larger amounts of husk raw material to purify the bioactive xanthones is advantageous, permitting additional preclinical assays or chemical transformations to enhance the biological activity of these substances. Copyright © 2015 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.5362
Affiliations:
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level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1195">1195</biblScope><biblScope unit="page" to="1201">1201</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2015-08">2015-08</date></imprint><idno type="ISSN">0951-418X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Based on the previously reported in vitro antiplasmodial activity of several xanthones from Garcinia mangostana, two xanthones, α‐mangostin and a new compound, δ‐mangostin, were isolated from mangosteen husk, and the in vitro antiplasmodial and cytotoxic effects were determined. α‐Mangostin was more active against the resistant Plasmodium falciparum chloroquine‐resistant (FCR3) strain (IC50 = 0.2 ± 0.01 μM) than δ‐mangostin (IC50 = 121.2 ± 1.0 μM). Furthermore, the therapeutic response according to the administration route was evaluated in a Plasmodium berghei malarial murine model. The greatest therapeutic response was obtained with intraperitoneal administration; these xanthones reduced parasitemia by approximately 80% with a daily dose of 100 mg/kg administered twice a day for 7 days of treatment. Neither compound was effective by oral administration. Noticeable toxicological effects were not observed. In addition to the antimalarial effect of these xanthones isolated from G. mangostana husk, the availability of larger amounts of husk raw material to purify the bioactive xanthones is advantageous, permitting additional preclinical assays or chemical transformations to enhance the biological activity of these substances. Copyright © 2015 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Colombie</li></country></list><tree><country name="Colombie"><noRegion><name sortKey="Upegui, Yulieth" sort="Upegui, Yulieth" uniqKey="Upegui Y" first="Yulieth" last="Upegui">Yulieth Upegui</name></noRegion><name sortKey="Archbold, Rosendo" sort="Archbold, Rosendo" uniqKey="Archbold R" first="Rosendo" last="Archbold">Rosendo Archbold</name><name sortKey="Echeverri, Fernando" sort="Echeverri, Fernando" uniqKey="Echeverri F" first="Fernando" last="Echeverri">Fernando Echeverri</name><name sortKey="Echeverri, Fernando" sort="Echeverri, Fernando" uniqKey="Echeverri F" first="Fernando" last="Echeverri">Fernando Echeverri</name><name sortKey="Escobar, Gustavo" sort="Escobar, Gustavo" uniqKey="Escobar G" first="Gustavo" last="Escobar">Gustavo Escobar</name><name sortKey="Gil Romero, Juan Fernando" sort="Gil Romero, Juan Fernando" uniqKey="Gil Romero J" first="Juan Fernando" last="Gil Romero">Juan Fernando Gil Romero</name><name sortKey="Nari O, Bibiana" sort="Nari O, Bibiana" uniqKey="Nari O B" first="Bibiana" last="Nari O">Bibiana Nari O</name><name sortKey="Qui Ones, Winston" sort="Qui Ones, Winston" uniqKey="Qui Ones W" first="Winston" last="Qui Ones">Winston Qui Ones</name><name sortKey="Robledo, Sara M" sort="Robledo, Sara M" uniqKey="Robledo S" first="Sara M." last="Robledo">Sara M. Robledo</name><name sortKey="Robledo, Sara M" sort="Robledo, Sara M" uniqKey="Robledo S" first="Sara M." last="Robledo">Sara M. Robledo</name><name sortKey="Robledo, Sara M" sort="Robledo, Sara M" uniqKey="Robledo S" first="Sara M." last="Robledo">Sara M. Robledo</name><name sortKey="Torres, Fernando" sort="Torres, Fernando" uniqKey="Torres F" first="Fernando" last="Torres">Fernando Torres</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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